Here is an interesting development in the field of biotech: digital bioprocess replicas.
While it sounds like it may be straight out of Blade Runner, the technology is very real and may soon revolutionize pharmaceuticals.
A “digital bioprocess replica” is, as the name suggests, a computer model of a bioprocess. The aim is to simulate the entire process, including all critical parameters and quality attributes, to enable optimization.
Data-rich bioprocess replicas can accelerate development, according to Jens Smiatek, PhD, from the Institute for Computational Physics at the Universität Stuttgart in Germany.
“Pharmaceutical manufacturing and process development can be improved by the early analysis of relevant critical process parameters (CPPs) and critical quality attributes (CQAs), the efficient determination of proven acceptable ranges (PARs) and less time-consuming exploratory experiments,” he says.