Jon Wood demonstrates how to use ML.NET within Python by using the NimbusML package. This video also gives an example of creating a linear regression model.

Notebook – https://github.com/jwood803/MLNetExamples/blob/master/MLNetExamples/Notebooks/NimbusML/Regression.ipynb

NimbusML documentation – https://docs.microsoft.com/en-us/nimbusml/overview